Adverse effect of topical steroid treatment on blood glucose control in a patient with type 2 diabetes on maintenance dialysis

DOI

Bibliographic Information

Other Title
  • ステロイド外用薬が血糖管理悪化の原因と推察された2型糖尿病維持透析患者の1例

Abstract

Controlling dyslipidemia is important to prevent cardiovascular events and the worsening of renal function in type 2 diabetic nephropathy with hyper-cholesterolemia(DNC). The present study aimed to compare the effects and safety of atorvastatin plus ezetimibe with atorvastatin in DNC. Patients were randomly allocated to group A (increased atorvastatin) or group E (added ezetimibe). The primary endpoint was the change in levels of non-HDL-C at 3 months after treatment intensification. Seventeen patients in each group completed the study. Non-HDL-C and LDL-C decreased in both groups, but the rate of change was significantly greater in group E and no difference in other parameters. Previous studies show that atorvastatin reduces urinary protein and improves kidney function in a dose-dependent manner in patients with CKD. In the present study, addition of ezetimibe showed superiority in the change of non HDL-C and LDL-C and showed equivalence in safety compared with increased atorvastatin in DNC.

Journal

Details 詳細情報について

  • CRID
    1390002212173528704
  • DOI
    10.15634/j0100_0401_002
  • ISSN
    21887527
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
  • Abstract License Flag
    Disallowed

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