Adverse effect of topical steroid treatment on blood glucose control in a patient with type 2 diabetes on maintenance dialysis
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- Kuribayashi Nobuichi
- Misaki Naika Clinic
Bibliographic Information
- Other Title
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- ステロイド外用薬が血糖管理悪化の原因と推察された2型糖尿病維持透析患者の1例
Abstract
Controlling dyslipidemia is important to prevent cardiovascular events and the worsening of renal function in type 2 diabetic nephropathy with hyper-cholesterolemia(DNC). The present study aimed to compare the effects and safety of atorvastatin plus ezetimibe with atorvastatin in DNC. Patients were randomly allocated to group A (increased atorvastatin) or group E (added ezetimibe). The primary endpoint was the change in levels of non-HDL-C at 3 months after treatment intensification. Seventeen patients in each group completed the study. Non-HDL-C and LDL-C decreased in both groups, but the rate of change was significantly greater in group E and no difference in other parameters. Previous studies show that atorvastatin reduces urinary protein and improves kidney function in a dose-dependent manner in patients with CKD. In the present study, addition of ezetimibe showed superiority in the change of non HDL-C and LDL-C and showed equivalence in safety compared with increased atorvastatin in DNC.
Journal
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- Diabetes Frontier Online
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Diabetes Frontier Online 4 (e1), 002-002, 2017-09-19
Medical Review Co.,Ltd
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Details 詳細情報について
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- CRID
- 1390002212173528704
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- ISSN
- 21887527
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed