Spike Propagation in Excitable Systems Enhanced by Membrane-Potential-Dependent Noise

説明

Until a few decades ago, noise was considered to be a factor that was responsible for the degradation in the performance of any electrical system, and indeed, there has been much research on the suppression of noisy signals. However, in the early 70's, a new phenomenon was observed in many physical as well as biological systems in which noise actually enhanced their performance under certain circumstances. Recently, Ochab-Marcinek et al. demonstrated that in myelinated axons having several intermediate nodes (known as Ranvier nodes), spike transmission initiated by sub-threshold stimuli can be enhanced by exploiting internal random fluctuations. Inspired by this work, we investigated how noise and its fluctuations enhance the performance of spike transmission in serially-connected electrically receiving sub-threshold inputs. Moreover, we also explored the effect of a membrane-potential-dependent dynamic noise as an alternative to avoiding spontaneous spike generation due to large noise fluctuations. Electrical simulations showed more than 20% increase in the transmission rate.

収録刊行物

  • IEICE Proceeding Series

    IEICE Proceeding Series 1 640-643, 2014-03-17

    The Institute of Electronics, Information and Communication Engineers

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詳細情報 詳細情報について

  • CRID
    1390002212174108672
  • DOI
    10.15248/proc.1.640
  • ISSN
    21885079
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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