Nanogel antigen DDS toward overcoming immune resistance of cancer

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  • ナノゲル抗原DDSによる免疫療法抵抗性がんの克服に向けて
  • ナノゲル コウゲン DDS ニ ヨル メンエキ リョウホウ テイコウセイ ガン ノ コクフク ニ ムケテ

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Abstract

In therapeutic cancer vaccine, it is important that vaccine antigen should be efficiently delivered at the appropriate time to antigen-presenting cells (dendritic cells and macrophages) located in lymphoid organs (lymph nodes and spleen) in order to induce higher anti-tumor immune response. We have developed novel cancer vaccines using cholesterol-substituted pullulan (CHP) nanogel as an antigen delivery system for targeted antigen delivery. In addition, recently we have proposed a new technology using CHP nanogel to regulate the functions of tumor-associated macrophages leading to the improvement of tumor microenvironment. When combined with other immunotherapies, modulation of macrophage function using CHP nanogel brings potent inhibitory effect on immune checkpoint inhibition-resistant cancer.

Journal

  • Drug Delivery System

    Drug Delivery System 35 (1), 64-69, 2020-01-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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