Study on the Changes of Chemical Constituents in Different Compatibilities of Ginseng-Prepared Rehmannia Root and Their Effects on Bone Marrow Inhibition after Chemotherapy

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  • Wang Si-qi
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Yang Xiao
    National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University
  • Zhang Yong-gang
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Cai En-bo
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Zheng Xiao-man
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Zhao Yan
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Li Ge
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Han Mei
    College of Chinese Medicinal Material, Jilin Agricultural University
  • Yang Li-min
    College of Chinese Medicinal Material, Jilin Agricultural University

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<p>Ginseng (G) and Prepared Rehmannia Root (PRR) are commonly used in traditional Chinese medicine for blood supplementation. This study aimed to study G and PRR with different compatibility ratios changes in chemical composition and inhibition of cyclophosphamide-induced myelosuppression. HPLC was used to determine the chemical constituents of 13 ginsenosides, 5-hydroxymethylfurfural (5-HMF) and verbascoside in different proportions of G-PRR. Balb/c mice were injected intraperitoneally with cyclophosphamide (CTX) to induce bone marrow suppression. The effects of different proportions of G-PRR on peripheral blood, bone marrow nucleated cells, thymus and spleen index of myelosuppressed mice were analyzed. The results showed that the compatibility of G and PRR can promote the dissolution of ginsenosides, and the content of conventional ginsenosides decreased, and the content of rare ginsenosides increased. Different proportions of G-PRR increased the number of peripheral blood and bone marrow nucleated cells in cyclophosphamide-induced bone marrow suppression mice (p < 0.01), increased thymus index (p < 0.01), decreased spleen index (p < 0.01). Different proportions of G-PRR can improve the myelosuppression induced by cyclophosphamide in mice, and the combined effect of G-PRR is better than the single decoction of G and PRR. Among them, G-PRR 2 : 3 and G-PRR 1 : 2 were better than the other groups. These results indicate that different proportion of G-PRR can improve bone marrow suppression, and the combined decoction of G-PRR is better than the separate Decoction in improving bone marrow suppression. This improvement may be related to the changes of the substance basis and active ingredients of G-PRR.</p>

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