Study on the Changes of Chemical Constituents in Different Compatibilities of Ginseng-Prepared Rehmannia Root and Their Effects on Bone Marrow Inhibition after Chemotherapy
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- Wang Si-qi
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Yang Xiao
- National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University
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- Zhang Yong-gang
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Cai En-bo
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Zheng Xiao-man
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Zhao Yan
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Li Ge
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Han Mei
- College of Chinese Medicinal Material, Jilin Agricultural University
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- Yang Li-min
- College of Chinese Medicinal Material, Jilin Agricultural University
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<p>Ginseng (G) and Prepared Rehmannia Root (PRR) are commonly used in traditional Chinese medicine for blood supplementation. This study aimed to study G and PRR with different compatibility ratios changes in chemical composition and inhibition of cyclophosphamide-induced myelosuppression. HPLC was used to determine the chemical constituents of 13 ginsenosides, 5-hydroxymethylfurfural (5-HMF) and verbascoside in different proportions of G-PRR. Balb/c mice were injected intraperitoneally with cyclophosphamide (CTX) to induce bone marrow suppression. The effects of different proportions of G-PRR on peripheral blood, bone marrow nucleated cells, thymus and spleen index of myelosuppressed mice were analyzed. The results showed that the compatibility of G and PRR can promote the dissolution of ginsenosides, and the content of conventional ginsenosides decreased, and the content of rare ginsenosides increased. Different proportions of G-PRR increased the number of peripheral blood and bone marrow nucleated cells in cyclophosphamide-induced bone marrow suppression mice (p < 0.01), increased thymus index (p < 0.01), decreased spleen index (p < 0.01). Different proportions of G-PRR can improve the myelosuppression induced by cyclophosphamide in mice, and the combined effect of G-PRR is better than the single decoction of G and PRR. Among them, G-PRR 2 : 3 and G-PRR 1 : 2 were better than the other groups. These results indicate that different proportion of G-PRR can improve bone marrow suppression, and the combined decoction of G-PRR is better than the separate Decoction in improving bone marrow suppression. This improvement may be related to the changes of the substance basis and active ingredients of G-PRR.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 68 (5), 428-435, 2020-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390003825178605952
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- NII論文ID
- 130007838797
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 030401502
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- PubMed
- 32188797
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可