Development of cancer-specific monoclonal antibodies against glycoproteins

DOI Web Site Web Site PubMed 8 References
  • Kato Yukinari
    New Industry Creation Hatchery Center, Tohoku University Department of Antibody Drug Development, Tohoku University Graduate School of Medicine

Bibliographic Information

Other Title
  • 先端的がん特異的抗体創製基盤技術開発とその臨床応用
  • センタンテキ ガン トクイテキ コウタイ ソウセイ キバン ギジュツ カイハツ ト ソノ リンショウ オウヨウ

Search this article

Abstract

<p>Many strategies have been tried to produce monoclonal antibodies (mAbs); however, there have been several problems about focusing on molecular targets and screening methods. For instance, the high tumor/normal ratio of antigen expression using DNA microarray has been thought to be important when we determine the molecular targets for antibody-drug. Although many antigens are expressed highly in tumors, those antigens have been removed from the candidates of antibody-drug targets because they were also expressed in normal tissues. We recently established a novel technology to produce a cancer-specific monoclonal antibody (CasMab). The post-translational difference such as glycans can be utilized to produce the CasMab, although the protein possesses the same amino acid sequence in both cancer and normal cells. We have already produced CasMabs against several glycoproteins such as podoplanin, which is expressed in both cancer and normal cells. Those CasMabs possess antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) in vitro and anti-tumor effect in xenograft models in vivo. In conclusion, the CasMab technology is the platform to develop cancer-specific mAbs, which could attack only cancer cells without side effects.</p>

Journal

References(8)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top