Protective Effect of Tong-Qiao-Huo-Xue Decoction on Inflammatory Injury Caused by Intestinal Microbial Disorders in Stroke Rats
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- Zhang Feng
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine Key Laboratory of Xin’an Medicine, Ministry of Education
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- Zhai Mengting
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine
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- Wu Qian
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine Key Laboratory of Xin’an Medicine, Ministry of Education
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- Jia Xiaoyi
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine Key Laboratory of Xin’an Medicine, Ministry of Education
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- Wang Yan
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine Key Laboratory of Xin’an Medicine, Ministry of Education
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- Wang Ning
- Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine Key Laboratory of Xin’an Medicine, Ministry of Education
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説明
<p>Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classic traditional Chinese medicine prescription for treating cerebral ischemia. The purpose of this study was to investigate the effect of TQHXD on intervening inflammatory response of ischemic stroke by regulating intestinal flora and repairing the intestinal barrier. A rat model of cerebral ischemia was established using middle cerebral artery occlusion (MCAO) and behavioral scores were performed. Additionally, the high throughput 16S ribosomal DNA (rDNA) sequence of intestinal bacteria in fecal samples of rat was also carried out. Our results showed that TQHXD could change the main components of intestinal flora in stroke rats, and reduced the excessive increase of Bacteroidetes, and also regulated the abnormal changes of abundance of some flora as well. In addition, the intestinal epithelial barrier was damaged after stroke, allowing bacterial metabolites to enter the blood, while TQHXD had an improved effect on this phenomenon. Meanwhile, pathological changes in the brain tissue and infarct volume were also alleviated by TQHXD. Due to the disorder of the intestinal flora and the destruction of the barrier, the peripheral immune imbalance caused an inflammatory reaction. TQHXD improved the imbalance of T cells, and inhibited the inflammatory response. Finally, the therapeutic transplantation of fecal microbiota also improved the outcome of stroke in rats. Our presented results suggest that TQHXD may improve the gut microbiota disorder and its induced inflammatory response after stroke, which could be a new target and mechanism for the treatment of stroke.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 43 (5), 788-800, 2020-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390003825178863616
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- NII論文ID
- 130007839272
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 030401659
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- PubMed
- 32132347
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- 本文言語コード
- en
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- 資料種別
- journal article
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- NDLサーチ
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- PubMed
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