Maternal and neonatal complications of pregnancies following fertility treatment.

DOI
  • Hamano Sena
    Department of Obstetrics and Gynecology in the Japanese Red Cross Narita Hospital
  • Sugita Tatsuya
    Department of Obstetrics and Gynecology in the Japanese Red Cross Narita Hospital
  • Kawato Hitoshi
    Department of Neonatology in the Japanese Red Cross Narita Hospital
  • Toishi Satoshi
    Department of Neonatology in the Japanese Red Cross Narita Hospital
  • Shimizu Kumiko
    Department of Obstetrics and Gynecology in the Japanese Red Cross Narita Hospital
  • Obata Shintaro
    Department of Obstetrics and Gynecology in the Japanese Red Cross Narita Hospital

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Other Title
  • 当院で分娩管理した不妊治療後妊娠の周産期予後に関する検討

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Abstract

<p> Objectives: The number of pregnancies following infertility treatment has been increasing worldwide. The aim of this study was to investigate the maternal and neonatal outcomes associated with infertility treatments.</p><p> Methods: We conducted a secondary data analysis using electronic clinical records from one hospital in Narita, Japan. We included all women who gave birth between 2015 and 2018（N＝2,243）. We compared outcomes of pregnancies achieved using an ART（ART group）or a general infertility treatment（Non-ART group）with the outcomes of unassisted pregnancies（natural pregnancy group）. We investigated 7 maternal outcomes and 6 neonatal outcomes. We conducted multiple logistic regression to assess the differences in outcomes while adjusting for potential confounders.</p><p> Results: We found a significantly higher risk of placenta previa in the general infertility treatment group（ORs＝2.41; 95％ CI＝1.03-5.63; p＝.043）and the ART group（ORs＝2.70; 95％ CI＝1.30-5.60; p ＜ .01）compared to the unassisted pregnancy group. The risks of major postpartum hemorrhage（ORs＝2.34; 95％ CI＝1.47-3.73, p ＜ .01）and low Apgar score at one minute（ORs＝1.81; 95％ CI＝1.05-3.11, p＝.034）were also higher in the ART group compared to the unassisted pregnancy group.</p><p> Conclusions: This study indicates a possibility of increasing adverse maternal and neonatal outcomes associated with infertility treatment. Further studies with a large sample from multiple settings are needed for developing robust evidence on the impact of infertility treatment and for the prevention of adverse outcomes.</p>

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