Expression and Post-translational Modification of Heat Shock Protein 27 (HSP27) in Cancer

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  • OYA-ITO TOMOKO
    Department of Nutrition, Shubun University
  • TAKAGI TOMOHISA
    Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine Department for Medical Innovation and Translational Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
  • SHIMA KEISUKE
    Shimadzu Corporation
  • NAITO YUJI
    Department of Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

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Other Title
  • がんにおける熱ショックタンパク質27（HSP27）のタンパク質発現とその翻訳後修飾
  • ガン ニ オケル ネツ ショックタンパクシツ 27(HSP27)ノ タンパクシツ ハツゲン ト ソノ ホンヤク ゴ シュウショク

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<p>Heat shock protein 27 (HSP27) is induced by heat shock, environmental, and pathophysiological stressors. HSP27 functions as a molecular chaperone and an anti-apoptotic protein in cells. Dynamic changes such as phosphorylation and oligomerization of HSP27 allow cells to adapt to changes in physiological functions and mount a protective response to damage. HSP27 is highly expressed in aggressive cancers, where it is involved in numerous pro-tumorigenic signaling pathways and is associated with poor prognosis and treatment resistant. This review focuses on the recent findings of the role of HSP27, particularly post-translational modification of HSP27 in cancer, and the strategies for therapeutic purposes by using HSP27 inhibitors.</p>

Journal

  • Thermal Medicine

    Thermal Medicine 36 (1), 1-24, 2020-03-15

    Japanese Society for Thermal Medicine

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