A case of human adjuvant disease with clinical features of Guillain-Barré syndrome
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- Takenouchi Akiyuki
- First Department of Medicine, Hamamatsu University School of Medicine
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- Hosoi Yasushi
- First Department of Medicine, Hamamatsu University School of Medicine
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- Watanabe Kazuki
- First Department of Medicine, Hamamatsu University School of Medicine
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- Takashima Hirotsugu
- First Department of Medicine, Hamamatsu University School of Medicine
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- Bunai Tomoyasu
- First Department of Medicine, Hamamatsu University School of Medicine Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine
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- Miyajima Hiroaki
- First Department of Medicine, Hamamatsu University School of Medicine
Bibliographic Information
- Other Title
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- ギラン・バレー症候群様に発症したヒトアジュバント病の1例
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Description
<p>A 69-year-old female developed subacute diplopia, right peripheral facial nerve palsy, bilateral upper and lower extremities dysesthesia and weakness 50 years after silicone injection for breast augmentation. Motor conduction study revealed prolonged distal latency and reduced amplitude in the median, ulnar, and peroneal nerves. Sensory conduction velocities were reduced in the median and ulnar nerves, and sensory potential in the sural nerve could not be recorded. While intravenous immunoglobulin therapy was ineffective, explantation of silicone breast implants improved her neurological symptoms. Histopathological study of axillary lymph node revealed foreign body granulomas and macrophages phagocyting silicone. The patient was diagnosed with human adjuvant disease presenting clinical features of Guillain-Barré syndrome. Human adjuvant disease should be considered in the patients with implants like silicone and neurological symptoms.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 60 (5), 358-361, 2020
Societas Neurologica Japonica
