Anti-tumor Activity and Survival Impact of Whole Adlay Hot Water Extract in Sarcoma Mouse Model

DOI Web Site Web Site 18 References
  • OKUWA-HAYASHI Hirotaka
    The Faculty of Food Culture, Kurashiki Sakuyo University
  • OHTA Tomihisa
    Kanazawa University, Venture Business Laboratory
  • OHNO Satoshi
    Clinical Research Support Center, Shimane University, Medical School
  • KYO Satoru
    Department of Obstetrics and Gynecology, Shimane University, Medical School
  • SUZUKI Nobutaka
    Deaprtment of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science

Bibliographic Information

Other Title
  • 肉腫モデルマウスにおけるハトムギ熱水抽出物の抗腫瘍効果と生存への影響

Search this article

Abstract

Background: Adlay (Coix lacryma-jobi L. var. ma-yuen Stapf) has been used both in traditional Chinese medicine and as a nourishing food based on its unique biological effects and highly nutritional values. In the present study, we investigated the anti-tumor effect of a hot-water adlay extract in sarcoma mice model. <br>Materials and Methods: The hot water extract of whole adlay was orally administered to mice for one week, after which Sarcoma-180 cells (1×106) were subcutaneously implanted into the abdomen. Thereafter, the tumor growth was monitored and mouse survival was examined. <br>Results: Tumor weights measured at 18 days were significantly lower in mice treated with extract (100 and 300 mg/kg/day) than those in control group (p<0.01). Moreover, mice treated with extract (100 mg/kg/day) showed apparently longer survival than control group evaluated until 32 days (p<0.05). <br>Conclusion: These findings indicate that hot water adlay extract appears to have some anti-tumor effects in vivo in sarcoma cells.

Journal

References(18)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top