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Elucidation of a mechanism of therapeutic effect on atopic dermatitis by Toyotomi hot spring bathing
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- Ishii Manami
- Faculty of Environment and Information Studies, Keio University
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- Murakami Shinnosuke
- Graduate School of Media and Governance, Keio University
Bibliographic Information
- Other Title
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- 豊富温泉入浴によるアトピー性皮膚炎抑制メカニズムの解明
- ホウフ オンセン ニュウヨク ニ ヨル アトピーセイ ヒフエン ヨクセイ メカニズム ノ カイメイ
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Description
<p>[Background]</p><p>Atopic dermatitis is a chronic, relapsing, intensely pruritic inflammatory skin disorder and it is difficult to completely cure. Recently, the therapeutic effect on atopic dermatitis by Toyotomi hot spring bathing has been reported. Therefore, the current study aimed to elucidate a mechanism of the effect.</p><p>[Methods]</p><p>In this study, a mouse model of atopic dermatitis was used. The therapeutic effect on atopic dermatitis of Toyotomi hot spring bathing and/or applying the oil that derived from Toyotomi hot spring was evaluated by comparing of severity scoring of atopic dermatitis (SCORAD), serum IgE level, and several types of gene expressions.</p><p>[Results]</p><p>The value of SCORAD was tended to decrease in oil (especially black oil) applying group as compared with the control group.</p><p>[Conclusion]</p><p>The results in this study suggested some compound that has the therapeutic effect on atopic dermatitis is included in the oil (especially black oil) derived from Toyotomi hot spring.</p>
Journal
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- Japanese Journal of Health and Research
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Japanese Journal of Health and Research 41 (0), 94-99, 2020-06-19
Japan Health & Research Institute
