Mirtazapine therapy for phantom limb pain after traumatic amputation: a case report

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  • HORIKAWA Hideyo
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • HATTORI Mizuki
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • TAKEMURA Yoshinori
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • HIBI Daisuke
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama
  • YAMAZAKI Mitsuaki
    Department of Anesthesiology, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama

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Other Title
  • 外傷による左上肢切断後の幻肢痛に対しミルタザピンが有効であった1例
  • 症例 外傷による左上肢切断後の幻肢痛に対しミルタザピンが有効であった1例
  • ショウレイ ガイショウ ニ ヨル ヒダリ ジョウシ セツダン ゴ ノ ゲンシツウ ニ タイシ ミルタザピン ガ ユウコウ デ アッタ 1レイ

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Abstract

<p>A 47-year-old man presented with severe phantom limb pain (PLP) seven days after amputation of the left brachium following an industrial accident. The initial pain was managed at the pain clinic using a continuous brachial plexus block and drug therapy. Consequently, his numerical rating scale (NRS) score for pain temporarily decreased from 5/10 to 2/10 during the nerve block treatment; however, pain intensified after the treatment ended. Subsequently, 15 mg of mirtazapine was administered once a day and increased to twice a day. Mirtazapine reduced the patient's NRS score to 3/10 for 8 h, which was not accomplished with other medicines. These observations indicate that mirtazapine has a unique pharmacological profile, unlike other antidepressants, and may be effective in improving PLP.</p>

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