Uterine artery embolization (UAE) for symptomatic uterine fibroids using microspheres as a safe and effective therapy

  • SOEJIMA Chikako
    Department of Obstetrics and Gynecology, Kansai Medical University
  • MIZOKAMI Tomomi
    Department of Obstetrics and Gynecology, Kansai Medical University
  • KITA Masato
    Department of Obstetrics and Gynecology, Kansai Medical University
  • HISAMATSU Yoji
    Department of Obstetrics and Gynecology, Kansai Medical University
  • IKUTA Akiko
    Department of Obstetrics and Gynecology, Kansai Medical University
  • KARIYA Shuji
    Department of Radiology, Kansai Medical University
  • TANIGAWA Noboru
    Department of Radiology, Kansai Medical University
  • OKADA Hidetaka
    Department of Obstetrics and Gynecology, Kansai Medical University

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Other Title
  • 症候性子宮筋腫に対するマイクロスフィアを用いた子宮動脈塞栓術の安全性と有効性
  • ショウコウセイ シキュウ キンシュ ニ タイスル マイクロスフィア オ モチイタ シキュウ ドウミャク ソクセンジュツ ノ アンゼンセイ ト ユウコウセイ

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Abstract

<p>Uterine artery embolization (UAE) is being established as an alternative to surgical treatment for symptomatic uterine fibroids. We retrospectively analyzed the medical records of 73 cases from December 2014 to June 2019, in which UAE using microspheres was performed for symptomatic uterine fibroids. Complications, rates of fibroid reduction after UAE, and the degree of improvement of subjective symptoms were examined. For comparison, we also analyzed 13 cases of UAE using gelatin sponges. UAE was performed by interventional radiologists, and the procedural success rate was 100%. The patient’s mean age were 45±7 years, and postembolization syndrome was the most profound complication, affecting all 73 cases. No uterine infections, sloughing, or other serious complications (such as necrosis, thrombosis or other organ damage) were observed. Pain within 24 hours post-UAE was milder when microspheres were used than when gelatin sponges were used. The mean volume ratio of dominant fibroid after 1-, 3-, 6-, and 12-months was 75%, 58%, 50%, and 45%, respectively. Subjective symptoms, such as abdominal swelling, dysmenorrhea, and menorrhagia, improved by 89%, 80%, 91%, respectively. UAE for symptomatic uterine fibroids using microspheres is safe and effective and could be alternative to traditional surgical treatments for women who wish to avoid hysterectomy. [Adv Obstet Gynecol, 72(2) :67-75, 2020(R2.5)]</p>

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