Analysis of Organoarsenic Compounds Concentration in Fish with the Newly Developed LC-MS/MS Method
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- Towatari Hironori
- Fukuoka City Institute of Health and Environment
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- Miyazaki Etsuko
- Fukuoka City Institute of Health and Environment
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- Akaki Koichi
- Fukuoka City Tatara Purification Plant
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- Nakamuta Keiko
- Fukuoka City Institute of Health and Environment
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- Kataoka Yohei
- National Institute of Health Sciences
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- Watanabe Takahiro
- National Institute of Health Sciences
Bibliographic Information
- Other Title
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- 新規開発したLC-MS/MS法を用いた魚に含まれる有機ヒ素化合物の分析
- シンキ カイハツ シタ LC-MS/MSホウ オ モチイタ サカナ ニ フクマレル ユウキ ヒソ カゴウブツ ノ ブンセキ
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Abstract
<p>Most fish contain some kinds of organoarsenic compounds. To assess the health risk for the chronic effects due to intake of these compounds, it is necessary to quantify the concentration of each chemical form, since the toxicity is difference depending on the form. We developed and validated the LC-MS/MS method to determine the concentration of monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), tetramethylarsonium (TeMA), arsenobetaine (AB), and arsenocholine (AC) in fish. Using this method, we quantified the concentration of each organoarsenic compounds and total arsenic in 50 fish samples from across 10 groups. Total arsenic concentration ranged from 0.53 to 25 mg/kg in all samples, except for in thread-sail filefish where the concentration ranged from 8.3 to 25 mg/kg. With the exception of sardines, in all samples AB was found at the highest level in relation to the total arsenic concentration. In sardines, the concentration of DMA was higher than that of AB, accounting for 16 to 24% of total arsenic. In red sea bream, concentrations of total arsenic, AB, and AC in farm-raised fish were lower than those in wild-caught fish.</p>
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 61 (3), 86-94, 2020-06-25
Japanese Society for Food Hygiene and Safety
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Details 詳細情報について
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- CRID
- 1390003825194549248
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- NII Article ID
- 130007867511
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- NII Book ID
- AN00117741
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- ISSN
- 18821006
- 00156426
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- NDL BIB ID
- 030529032
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- PubMed
- 32611948
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed