Lymphoid stromaを伴うEBV関連早期胃癌の1例

  • 坂倉 明恵
    筑波大学附属病院水戸地域医療教育センター水戸協同病院 総合診療科
  • 有賀 啓之
    筑波大学附属病院水戸地域医療教育センター水戸協同病院 消化器内科
  • 熊倉 有里
    筑波大学附属病院水戸地域医療教育センター水戸協同病院 消化器内科
  • 鹿志村 純也
    筑波大学附属病院水戸地域医療教育センター水戸協同病院 消化器内科


  • A case of Epstein-Barr virus-associated carcinoma with lymphoid stroma



<p>A 69-year-old woman visited our hospital for gastric abnormality in the upper gastrointestinal series. She had no subjective symptoms. Blood examination including tumor marker revealed normal levels. A gastrointestinal endoscopic study revealed a stage 0-IIc-like lesion of the stomach body. Histological findings of the biopsy specimen revealed gastric carcinoma with lymphoid stroma on hematoxylin and eosin staining, and the tumor cells were positive for the in situ hybridization of Epstein-Barr virus (EBV) -encoded small RNAs. Enhanced computed tomography images revealed no metastasis to lymph nodes and other organs in the chest and abdomen. Therefore, the diagnosis was gastric carcinoma with lymphoid stroma-associated EBV (clinical stage IA), and surgery was performed. The frequency of EBV-associated carcinoma is not small and it has poor subjective symptoms; hence, its discrimination by characteristic clinical pathology findings is necessary.</p>


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