Large olfactory neuroblastoma with en bloc resection by an endonasal endoscopic approach and transorbital approach: A case report

  • Tsumura Munechika
    Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
  • Makihara Seiichiro
    Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
  • Omura Kazuhiro
    Department of Otorhinolaryngology, the Jikei University School of Medicine
  • Naito Tomoyuki
    Department of Otolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital
  • Matsumoto Junya
    Department of Otolaryngology, Kochi Health Sciences Center
  • Kariya Shin
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Okano Mitsuhiro
    Department of Otorhinolaryngology, International University of Health and Welfare, School of Medicine
  • Nishizaki Kazunori
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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Other Title
  • 経眼窩アプローチを併用し,内視鏡下に一塊切除した嗅神経芽細胞腫例

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Abstract

Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the midline ventral skull base. Open craniofacial resections have been the treatment of choice for many years. More recently, experience has been growing with endoscopic resection in the management of patients with ONB. It is also controversial whether ONB should be removed by en bloc resection or multilayer resection. <br>The present case was a 70-year-old man with ONB filling both the nasal cavity with dural invasion, which was classified as a Kadish stage C, and a Dulguerov and Calcaterra stage T4. The chief complaint was olfactory disturbance. For en bloc resection, the endoscopic endonasal resection approach was selected with the transorbital approach for ligation of the anterior and posterior ethmoid arteries. <br>This case study shows that ethmoid arteries of a large ONB filling the nasal cavity, which is difficult to approach endonasally, can be approached transorbitally and ligated, and ONB can be removed by en bloc resection.

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