A case of sporadic late-onset nemaline myopathy associated with myasthenia gravis positive for anti-titin antibody and anti-Kv1.4 antibody
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- M.D. Kanatani Masahiro
- Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
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- M.D., Ph.D. Adachi Tadashi
- Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
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- M.D. Sakata Ryoichi
- Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
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- M.D., Ph.D. Watanabe Yasuhiro
- Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
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- M.D., Ph.D. Hanajima Ritsuko
- Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
Bibliographic Information
- Other Title
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- 抗横紋筋抗体陽性の重症筋無力症に合併したsporadic late-onset nemaline myopathyの1例
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Abstract
<p>A 66-year-old woman who had myasthenia gravis (MG) admitted for type II respiratory failure and right heart failure. Although she had neither ptosis, eye movement disorder, nor diplopia, she had orbital muscles weakness, reduction of gag reflex, dysarthria, dysphagia, and mild proximal muscle weakness. Blood tests showed anti-striated muscle antibodies (anti-titin antibody and anti-Kv1.4 antibody). A muscle biopsy of the left biceps showed a marked variation in fiber size, mild mononuclear cell infiltration was seen surrounding blood vessels in perimysium and nemaline bodies in some fibers. Immunohistochemical stains showed many muscle fibers express HLA-ABC. The patient was diagnosed as sporadic late-onset nemaline myopathy (SLONM) with MG, and treated by tacrolimus. After treatment, her respiratory function gradually improved and she discharged. In the case of atypical MG, measurement of anti-striated muscle antibody or muscle biopsy should be considered.</p>
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 60 (7), 489-494, 2020
Societas Neurologica Japonica