10-Hydroxydecanoic Acid Potentially Elicits Antigen-Specific IgA Responses

DOI Web Site Web Site PubMed 参考文献15件
  • Isayama Tatsuya
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Etoh Hikaru
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Kishimoto Naoki
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Takasaki Toshimasa
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Kuratani Ayumi
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Ikuta Tomoki
    Institute for Bee Products and Health Science, Yamada Bee Company, Inc.
  • Tatefuji Tomoki
    Institute for Bee Products and Health Science, Yamada Bee Company, Inc.
  • Takamune Nobutoki
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
  • Muneoka Atsunobu
    Shin Nippon Biomedical Laboratories, Ltd.
  • Takahashi Yoshihiro
    Shin Nippon Biomedical Laboratories, Ltd.
  • Misumi Shogo
    Department of Environmental and Molecular Health Sciences, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

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<p>The effective antigen (Ag) uptake by microfold cells (M-cells) is important for the induction of an efficient mucosal immune responses. Here, we show that 10-hydroxydecanoic acid (10-HDAA) from royal jelly (RJ) potentially supports M-cell differentiation and induces effective antigen-specific mucosal immune responses in cynomolgus macaques. 10-HDAA increases the expression level of receptor activator of nuclear factor-kappaB (NF-κB) (RANK) in Caco-2 cells, which suggests that 10-HDAA potentially prompts the differentiation of Caco-2 cells into M-cells and increased transcytosis efficiency. This idea is supported by the following observations. Intranasal administration of 10-HDAA increased the number of M-cells in the epithelium overlying nasopharynx-associated lymphoid tissue (NALT) in macaques. Oral administration of 10-HDAA increased the number of M-cells in the follicle-associated epithelium (FAE) covering Peyer’s patches (PPs) and significantly increased the antigen-specific immunoglobulin A (IgA) level in macaques. These findings suggest that the exogenous honeybee-derived medium-chain fatty acid 10-HDAA may effectively enhance antigen-specific immune responses.</p>

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