Effects of intragastric administration of La<sub>2</sub>O<sub>3</sub> nanoparticles on mouse testes

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  • Yuan Lu
    College of Public Health, North China University of Science and Technology, China
  • Bai Disi
    College of psychology, North China University of Science and Technology, China
  • Meng Lijun
    Department of Environmental and Chemical Engineering, Tangshan University, China
  • Wang Hong
    College of psychology, North China University of Science and Technology, China
  • Sun Zhaoyu
    College of psychology, North China University of Science and Technology, China
  • An Tianyang
    College of Ji Tang, North China University of Science and Technology, China
  • Chen Zhenfei
    Environmental Monitoring Center of Tang Shan, China
  • Deng Xuenan
    Department of Social science, Tangshan Normal University, China
  • Zhang Xiujun
    College of Public Health, North China University of Science and Technology, China

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  • Effects of intragastric administration of La₂O₃ nanoparticles on mouse testes

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<p>Lanthanum oxide (La2O3) nanoparticles (NPs) have been widely used in photoelectric and catalytic applications. However, their exposure and reproductive toxicity is unknown. In this study, the effect of the intragastric administration of two different-sized La2O3 particles in the testes of mice for 60 days was investigated. Although the body weight of mice treated or not treated with La2O3 NPs was not different and La2O3 NPs were distributed in the organs including the testis, liver, kidney, spleen, heart and brain. La2O3 NPs accumulate more than micro-sized La2O3 (MPs) in mice testes. The histopathological evaluation showed that moderate reproductive toxicity induced by La2O3 NPs in the testicle tissues. Furthermore, increased MDA, 8-OHdG levels and decreased SOD activities were detected in the La2O3 NP-treated groups. Moreover, qRT-PCR and western blotting data indicated that La2O3 NPs affecting the blood–testis barrier (BTB)-related genes in mice testes. Taken together, these findings suggested that La2O3 NPs activated inflammation responses and cross the BTB in the murine testes. This study provided useful information for risk analysis and regulation of La2O3 NPs by administrative agencies.</p>

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