Development of Method for Monitoring Field Potential of hiPSC by Using Ultra-thin Film Electronics

DOI
  • Ohya Takashi
    Department of Modern Mechanical Engineering, Graduate School of Creative science and Engineering, Waseda University, Tokyo, Japan JSPS Research Fellowship for Young Scientists (DC1) , Tokyo, Japan
  • Ohtomo Haruki
    Department of Modern Mechanical Engineering, Graduate School of Creative science and Engineering, Waseda University, Tokyo, Japan
  • Kikuchi Tetsutaro
    Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan
  • Sasaki Daisuke
    Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan
  • Matsuura Katsuhisa
    Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan
  • Shimizu Tatsuya
    Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Tokyo, Japan
  • Fukuda Kenjiro
    RIKEN Thins-film device laboratory and Center for Emergent Mater Science, Saitama, Japan
  • Someya Takao
    RIKEN Thins-film device laboratory and Center for Emergent Mater Science, Saitama, Japan
  • Umezu Shinjiro
    Undergraduate School of Creative Science and Engineering, Waseda University, Tokyo, Japan

Bibliographic Information

Other Title
  • 超薄膜電極を利用したヒトiPS細胞由来心筋細胞の細胞外電位低侵襲モニタリング手法の開発

Abstract

<p>In Japan, reducing drug discovery costs is a major issue. Currently, preclinical studies are mainly conducted by animal experiments, but humans and animals do not always show the same drug effects. In order to solve this problem, research on establishing a drug evaluation system using an in vitro tissue constructed from human iPS cell-derived cardiomyocytes has attracted attention. In this study, we developed an ultra-thin 500 nm-thick sensor which can monitor field potential of cardiomyocytes while following beating. By using the ultra-thin film electronics, we succeeded in measuring field potential in multiple channels while following the beating of human iPS cell-derived cardiomyocytes. In addition, we succeeded in monitoring drug effect of adrenaline from the field potential waveform. Therefore the thin-film electronics is considered to be effective as a sensor for evaluating the drug response of human iPS cell-derived cardiomyocytes .</p>

Journal

Details 詳細情報について

  • CRID
    1390003825204152832
  • NII Article ID
    130007884879
  • DOI
    10.11239/jsmbe.annual58.112
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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