In vitro evaluation of osteoinhibition response of MC3T3-E1 on DLC coated titanium scaffolds

DOI
  • KUBOTA Kosuke
    Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan
  • SANADA Shokichi
    Department of Medical Engineering and Technology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
  • YOSHIDA Kazuhiro
    Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan Department of Medical Engineering and Technology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
  • SAKAI Rina
    Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan Department of Medical Engineering and Technology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan
  • UJIHIRA Masanobu
    Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan Department of Medical Engineering and Technology, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan

Bibliographic Information

Other Title
  • DLCコーティングチタン上におけるMC3T3-E1骨芽細胞様細胞の骨形成抑制評価

Abstract

<p>For titanium and its alloy removal implant devices, adhesion with bone might cause difficulty removing the implanted devices during removal operation. We thought that Diamond Like Carbon (DLC) coated on titanium could be a material to inhibit adhesion to bone. The purpose of this study was to evaluation of osteoinhibition response of pre-osteoblast cells on the DLC coated titanium scaffolds.Commercially pure titanium grade 2 plate was coated with DLC by ionization deposition method. The MC3T3-E1 pre-osteoblast seeded on DLC coated and uncoated titanium plates for 4 days cultivation. Then, the number of cells was counted and the ALP activity was measured.The ALP activity normalized by cell number of DLC coated titanium showed a significantly lower value than the titanium. It was suggested that the DLC coated titanium devices could inhibit adhesion to bone.</p>

Journal

Details 詳細情報について

  • CRID
    1390003825204348416
  • NII Article ID
    130007885147
  • DOI
    10.11239/jsmbe.annual58.473
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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