Clinical outcomes of cervical intraepithelial neoplasia grade 2 in our hospital

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  • NISHIDA Hidetaka
    Department of Obstetrics and Gynecology, Kyoto Min-iren Chuo Hospital
  • NAKAMURA Misako
    Department of Obstetrics and Gynecology, Kyoto Min-iren Chuo Hospital
  • FURUITA Noriko
    Department of Obstetrics and Gynecology, Kyoto Min-iren Chuo Hospital
  • YAMANISHI Ayumi
    Department of Obstetrics and Gynecology, Kyoto Min-iren Chuo Hospital

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Other Title
  • 当院で子宮頸部上皮内腫瘍（CIN2）と判断・管理した症例の臨床的検討
  • トウ イン デ シキュウ ケイブ ジョウヒ ナイ シュヨウ(CIN2)ト ハンダン ・ カンリ シタ ショウレイ ノ リンショウテキ ケントウ

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Abstract

<p>To estimate the clinical outcomes of women with cervical intraepithelial neoplasia grade 2 (CIN2), we retrospectively investigated the outcomes and prognosis of 58 women with CIN2 treated in our hospital over the previous 15 years. We recognized that there were numerous cases with "CIN1-2" and "CIN2-3" lesions, these being the interim terms to classify lesions that could not be differentiated between CIN1 and CIN2 or between CIN2 and CIN3, respectively. Therefore, we also included 32 CIN1-2 and 43 CIN2-3 cases in our study. CIN1-2 and CIN2 regressed in 63% and 64%, respectively, of women kept under surveillance. For women younger than 30, the rate of regression was more favorable (89% and 75%, respectively). The rate of progression was 16% for CIN1-2, 16% for CIN2, and 12% for CIN2-3. Thirty-six patients with CIN2-3 underwent immediate cervical conization, 28 of whom (84%) were restaged as CIN3 after surgery. Our results suggest that CIN2 will regress in about 60% of women kept under surveillance. Conservative management with active surveillance, instead of immediate local excision, is therefore acceptable in selected patients, especially if further pregnancies are considered and compliance with surveillance is likely to be high. [Adv Obstet Gynecol, 72(3) : 205-210, 2020 (R2.8)]</p>

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