Pembrolizumab-induced Radiation Recall Pneumonitis After the Resolution of Typical Asymptomatic Radiation Pneumonitis

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  • ITAMURA Hirohide
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • OHGURI Takayuki
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • YAHARA Katsuya
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • NAKAHARA Sota
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • KAKINOUCHI Sho
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • MORISAKI Takahiro
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan
  • YATERA Kazuhiro
    Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • TANAKA Fumihiro
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
  • KOROGI Yukunori
    Department of Radiology, School of Medicine, University of Occupational and Environmental Health, Japan

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Other Title
  • 典型的な無症候性放射線肺臓炎の消退後に投与されたペンブロリズマブにより誘発された放射線リコール肺臓炎

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<p>Radiation recall pneumonitis is a phenomenon in which a recall-triggering drug induces an acute inflammatory reaction in the lungs, corresponding to a previously irradiated area. Radiation recall reactions have been reported to occur following treatments with various cytotoxic anticancer agents and molecular-targeting drugs; however, only a few reports have described immune checkpoint inhibitor-induced radiation recall pneumonitis. We report a case of radiation recall pneumonitis induced by pembrolizumab in a patient with the postoperative local recurrence of non-small cell lung cancer. This case demonstrated that pembrolizumab might cause severe radiation recall pneumonitis, even after typical radiation pneumonitis has been resolved.</p>

Journal

  • Journal of UOEH

    Journal of UOEH 42 (3), 261-266, 2020-09-01

    The University of Occupational and Environmental Health, Japan

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