Effect of sodium arsenite on the blood coagulation-fibrinolytic system in cultured vascular endothelial cells and macrophage-like THP-1 cells

DOI
  • NAKANO Tsuyoshi
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • ARAKI Yumi
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • TAKAHASHI Tsutomu
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • YAMAMOTO Chika
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Toho University
  • KAJI Toshiyuki
    Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • FUJIWARA Yasuyuki
    Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Bibliographic Information

Other Title
  • 血管内皮細胞及びマクロファージ様細胞の血液凝固線溶系に対する亜ヒ酸の作用

Abstract

<p>Arsenic is an environmental pollutant that causes atherosclerosis. In this study, we found that arsenite inhibits the fibrinolytic activity through NRF2-dependent suppression of t-PA expression in vascular endothelial cells, whereas arsenite upregulated the expression of PAI-1 and tissue factor in macrophage-like THP-1 cells. These results suggest that arsenite decreases the fibrinolytic activity in blood vessels through disruption of the coagulation-fibrinolytic system in vascular endothelial cells and macrophages, resulting in a promotion of atherosclerosis progression.</p>

Journal

Details 詳細情報について

  • CRID
    1390004222614728960
  • NII Article ID
    130007898191
  • DOI
    10.14869/toxpt.47.1.0_p-11s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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