Investigation of HLA allotype-specific skin toxicity by abacavir using HLA transgenic mice
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- YAMADA Yushiro
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- AOKI Shigeki
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- FUJIMORI Sota
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- ITO Kousei
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Bibliographic Information
- Other Title
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- HLA遺伝子導入マウスを用いたアバカビルによるHLA多型依存的な皮膚毒性発症機構の検討
Abstract
<p>[Aim] We investigated drug reactions in keratinocytes (KCs) by focusing on the interaction between HLA-B*57:01 and abacavir (ABC) using our originally produced HLA-B*57:01 transgenic mice (B*57:01-Tg).</p><p>[Results] ABC exposure increased mRNA expression of IFN-γ and immunoproteasome (IP) subunits induced by IFN-γ in KCs derived from B*57:01-Tg. In addition, ABC exposure increased protein expression of IP subunits in skin tissue of B*57:01-Tg. These results imply that increased IP expression by ABC exposure in KCs expressing HLA-B*57:01 might produce specific antigens and induce immunotoxicity.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-62S-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390004222614884224
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- NII Article ID
- 130007898350
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed