Involvement of immune tolerance systems in the onset of HLA allele-specific drug-induced immunotoxicity
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- AOKI Shigeki
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- KUWAHARA Saki
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- SUSUKIDA Takeshi
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
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- ITO Kousei
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Bibliographic Information
- Other Title
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- HLA多型特異的な薬物性の免疫毒性発症に対する免疫寛容系の関与
Abstract
<p>[Aim] We generated a transgenic mouse carrying HLA-B*57:01 to reproduce abacavir-induced idiosyncratic toxicity. Here, to observe clear toxic phenotype, we eliminated immunosuppressive factors (PD-1 and CD4+ T cells) in the mouse.</p><p>[Results] Depleting CD4+ T cells increased memory CD8+ T cells by exposure to abacavir, and exacerbated PD-1 expression. In addition, depletion of CD4+ T cells in HLA-B*57:01-Tg/PD-1-/- dramatically increased memory CD8+ T cells and induced skin redness. These results infer blockade of immunosuppression should be important in reproducing HLA-mediated immunotoxicity.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-61E-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390004222614894080
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- NII Article ID
- 130007898355
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed