Involvement of immune tolerance systems in the onset of HLA allele-specific drug-induced immunotoxicity

DOI
  • AOKI Shigeki
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • KUWAHARA Saki
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • SUSUKIDA Takeshi
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
  • ITO Kousei
    Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University

Bibliographic Information

Other Title
  • HLA多型特異的な薬物性の免疫毒性発症に対する免疫寛容系の関与

Abstract

<p>[Aim] We generated a transgenic mouse carrying HLA-B*57:01 to reproduce abacavir-induced idiosyncratic toxicity. Here, to observe clear toxic phenotype, we eliminated immunosuppressive factors (PD-1 and CD4+ T cells) in the mouse.</p><p>[Results] Depleting CD4+ T cells increased memory CD8+ T cells by exposure to abacavir, and exacerbated PD-1 expression. In addition, depletion of CD4+ T cells in HLA-B*57:01-Tg/PD-1-/- dramatically increased memory CD8+ T cells and induced skin redness. These results infer blockade of immunosuppression should be important in reproducing HLA-mediated immunotoxicity.</p>

Journal

Details 詳細情報について

  • CRID
    1390004222614894080
  • NII Article ID
    130007898355
  • DOI
    10.14869/toxpt.47.1.0_p-61e
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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