Prediction of drug-induced convulsion by using heart rate variability in monkeys

DOI

Bibliographic Information

Other Title
  • 心拍変動解析によるサルの薬物誘発性痙攣の予測

Description

<p>Convulsion causes significant impact on drug development but there is no good biomarker. The aim of this study was to investigate the potential of heart rate variability (HRV) as novel biomarker for drug-induced convulsion in monkeys. Telemetry-implanted monkeys were dosed with convulsants, and HRV was analyzed for 3 hours after dosing by multivariate statistical process management. As a result, frequency and duration of alarms were tended to be increased by picrotoxin and penthylentetrazole. It suggests HRV is useful for predicting drug-induced convulsions in monkeys.</p>

Journal

Details 詳細情報について

  • CRID
    1390004222615074432
  • NII Article ID
    130007898547
  • DOI
    10.14869/toxpt.47.1.0_p-77e
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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