Understanding of unrecognized effects of low molecular weight compounds by a decomposition analysis

DOI
  • MIZUNO Tadahaya
    Molecular Pharmacokinetics, Pharmaceutical Sciences, The University of Tokyo
  • MORITA Katsuhisa
    Molecular Pharmacokinetics, Pharmaceutical Sciences, The University of Tokyo
  • NEMOTO Shumpei
    Molecular Pharmacokinetics, Pharmaceutical Sciences, The University of Tokyo
  • KUSUHARA Hiroyuki
    Molecular Pharmacokinetics, Pharmaceutical Sciences, The University of Tokyo

Bibliographic Information

Other Title
  • 作用分離解析による化合物が持つ潜在的な側面の理解

Description

<p>Low molecular weight compounds such can interact with multiple targets, which often causes harmful unrecognized effects, even by the developers. To understand the multiple effects of a compound, omics analysis is a suitable choice because it converts the biological information of a specimen into the numeric one without bias, based on its comprehensiveness.</p><p>We have developed a novel analysis method, orthogonal linear separation analysis (OLSA), whose advantage is easiness for biologists to understand the outcome of the unbiased data analysis. We introduce the framework and the application.</p>

Journal

Details 詳細情報について

  • CRID
    1390004222615124864
  • NII Article ID
    130007898635
  • DOI
    10.14869/toxpt.47.1.0_s9-1
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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