書誌事項
- タイトル別名
-
- Design and Synthesis of Protecting Groups for Pro-oligo Type Nucleic Acid-based Drugs
- プロオリゴガタ カクサン イヤク オ シコウ シタ ホゴキ ノ カイハツ ケンキュウ
この論文をさがす
抄録
<p>Oligonucleotide-based therapeutics, such as antisense oligonucleotides and small interfering RNAs(siRNAs), are fast emerging as the next generation of chemotherapeutics. However, a major issue for oligonucleotide-based therapeutics involves effective intracellular delivery of the active molecules into the cells. Several methods such as lipid nanoparticle encapsulation and conjugation of functional molecules have been reported. As an alternative approach, the use of pro-oligonucleotides (pro-oligos) offers several advantages, including improved enzymatic stability, thereby avoiding the need for transfection reagents for the delivery of oligonucleotides into cells. We have developed several bio-labile protecting groups for the pro-oligos. This article describes the design and synthesis of bio-labile protecting groups and their application to pro-oligo type molecules for the development of oligonucleotide therapeutics.</p>
収録刊行物
-
- 有機合成化学協会誌
-
有機合成化学協会誌 78 (9), 886-893, 2020-09-01
公益社団法人 有機合成化学協会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390004222615175040
-
- NII論文ID
- 130007898711
-
- NII書誌ID
- AN0024521X
-
- ISSN
- 18836526
- 00379980
-
- NDL書誌ID
- 030651920
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可