HTLV-1-associated myelopathy

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  • YAMANO Yoshihisa
    Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine

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  • HTLV-1関連脊髄症（HAM）
  • HTLV-1 カンレン セキズイショウ(HAM)

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Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that infects T lymphocytes. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an intractable neurodegenerative disease caused by HTLV-1 infection just like adult T cell leukemia/lymphoma (ATL) is, developing in a fraction of infected individuals. Here, we review the update information about the new drug development and therapeutic algorithm of HAM/TSP based on the resent research achievement in molecular pathogenesis and biomarkers.

Journal

  • Uirusu

    Uirusu 69 (1), 29-36, 2019

    The Japanese Society for Virology

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