Multiple myeloma with light chain deposition disease showing needle-like crystal inclusions in plasma cells and macrophages in multiple organs

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  • 形質細胞内と多臓器のマクロファージに針状の結晶封入体を認めたlight chain deposition disease合併多発性骨髄腫
  • 症例報告 形質細胞内と多臓器のマクロファージに針状の結晶封入体を認めたlight chain deposition disease合併多発性骨髄腫
  • ショウレイ ホウコク ケイシツ サイボウ ナイ ト タゾウキ ノ マクロファージ ニ シンジョウ ノ ケッショウ フウニュウタイ オ ミトメタ light chain deposition disease ガッペイ タハツセイ コツズイシュ

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Abstract

<p>A 57-year-old Japanese man was referred to our hospital with the chief complaint of dizziness. Our investigations showed pancytopenia that necessitated bone marrow evaluation; this evaluation revealed plasma cell proliferation that was accompanied by numerous needle-shaped crystal inclusions. Clinical and laboratory examinations were used to establish a diagnosis of multiple myeloma (MM) accompanied by Fanconi syndrome. He was administered treatment with bortezomib, lenalidomide, or thalidomide; however, he died after experiencing upper abdominal pain of unknown etiology. Histopathological examination showed needle-like inclusions in the liver and kidney and macrophages in the bone marrow, suggesting light chain deposition disease (LCDD) that could contribute to multi-organ injury. We report the rare case of a patient with needle-shaped inclusions in MM that caused LCDD.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 61 (11), 1620-1624, 2020

    The Japanese Society of Hematology

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