Efficacy and safety of edoxaban following danaparoid sodium administration for treatment of portal vein thrombosis in patients with cirrhosis
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- Yuko Nagaoki
- Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University
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- Hiroshi Aikata
- Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University Liver Research Project Center, Hiroshima University
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- Kazuaki Chayama
- Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, Hiroshima University Liver Research Project Center, Hiroshima University Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences
Bibliographic Information
- Other Title
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- 肝硬変合併門脈血栓症に対するダナパロイドNa先行エドキサバンの有効性,安全性
- 肝硬変合併門脈血栓症に対するダナパロイドNa先行エドキサバンの有効性,安全性 : warfarinとの比較
- カンコウヘン ガッペイ モンミャク ケッセンショウ ニ タイスル ダナパロイド Na センコウ エドキサバン ノ ユウコウセイ,アンゼンセイ : warfarin ト ノ ヒカク
- ―warfarinとの比較―
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Abstract
<p>Aim: To evaluate the efficacy and safety of edoxaban in comparison with warfarin for treatment of portal vein thrombosis (PVT) following danaparoid sodium administration in patients with cirrhosis.</p><p>Methods: 64 cirrhotic patients with PVT treated initially for 2 weeks by danaparoid sodium were enrolled retrospectively. In all patients, either edoxaban (n = 34) or warfarin (n = 30) were administrated then later. The efficacy and safety of edoxaban were compared to those of warfarin for up to 6 months. PVT volume was measured by dynamic CT at baseline and at 2 weeks, 1, 3 and 6 months.</p><p>Results: Significant differences in clinical characteristics of patients were not found between both groups. Edoxaban intakes reduced volume of PVT from 1.72 cm3 at 2 weeks to 0.44 cm3 at 6 months, and prevented exacerbation of PVT at 6 months after treatment with danaparoid sodium (p = 0.008). Warfarin intakes, however, resulted in increase of PVT volume from 1.37 cm3 at 2 weeks to 2.65 cm3 at 6 months, despite that prothrombin time international normalized ratio (INR) of 1.5 or more was maintained in 57% of patients (p = 0.005). Multivariate regression analysis identified edoxaban therapy as a single significant and independent determinant contributing PVT reduction at 6 months (p<0.001). Gastrointestinal bleeding occurred in 4 of 34 (12%) patients in the edoxaban group, while 2 of 30 (7%) in the warfarin group (p = 0.485).</p><p>Conclusion: Edoxaban intakes following danaparoid sodium administration were effective and merit consideration as one of therapeutic options for PVT in cirrhotic patients.</p>
Journal
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- Japanese Journal of Portal Hypertension
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Japanese Journal of Portal Hypertension 24 (4), 224-230, 2018
The Japan Society for Portal Hypertension
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Details 詳細情報について
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- CRID
- 1390005506386124928
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- NII Article ID
- 130007960952
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- NII Book ID
- AA11349565
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- ISSN
- 21866376
- 13448447
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- NDL BIB ID
- 029509498
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed