A case of acute steatosis induced by chemotherapy for colon cancer
-
- Kitamura Hiroshi
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Matsumura Hideyasu
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Nakagawa Kan
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Matsushita Akimasa
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Arai Masayuki
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Koike Shoichiro
- Department of Surgery, National Hospital Organization Matsumoto Medical Center
-
- Oya Maki
- Department of Pathology, National Hospital Organization Matsumoto Medical Center
-
- Nakazawa Isao
- Department of Pathology, National Hospital Organization Matsumoto Medical Center
Bibliographic Information
- Other Title
-
- 大腸癌化学療法による薬物性急性脂肪肝が疑われた1例
- ダイチョウ ガン カガク リョウホウ ニ ヨル ヤクブツセイ キュウセイ シボウカン ガ ウタガワレタ 1レイ
Search this article
Description
<p>A 66-year-old male patient received systemic chemotherapy for metastatic colon cancer. During the introduction of the 38th dose of the 5-FU based regimen (5FU+folinic acid+irinotecan), he exhibited general fatigue followed by acute steatosis with liver dysfunction, accompanied by a steep decline of serum albumin and ascites formation. After cessation of the chemotherapeutic drug and receiving supportive care for hepatic dysfunction, the hepatic dysfunction rapidly improved. Following this episode, the effective chemotherapy continued for 32 months, until the patient's death due to interstitial pneumonia (The entire survival time was 68 months.). The regeneration of the hepatic volume was normal following three hepatectomies for his liver metastases. The histological findings harvested 12 months prior to the hepatic failure presented almost normal parenchyma of the background liver. Although irinotecan was the most suspicious cause for the steatosis, an acute form of the hepatic failure has hardly been reported before this case.</p>
Journal
-
- Kanzo
-
Kanzo 62 (1), 1-7, 2021-01-01
The Japan Society of Hepatology
- Tweet
Details 詳細情報について
-
- CRID
- 1390005506398245760
-
- NII Article ID
- 130007967864
-
- NII Book ID
- AN00047770
-
- ISSN
- 18813593
- 04514203
-
- NDL BIB ID
- 031218042
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed