認知症における髄液バイオマーカー：特発性正常圧水頭症マーカーとしての髄液中の“脳型”トランスフェリン

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  • A biomarker for idiopathic normal pressure hydrocephalus : “Brain-type” transferrin in cerebrospinal fluid

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<p>Glycan structures of glycoproteins are often cell–type specific, suggesting that glycan isoforms could be cell type–specific biomarkers. Two glycan isoforms of transferrin (Tf) were found in cerebrospinal fluid (CSF), i.e., brain–type Tf and serum–type Tf. Serum–type Tf appears to be derived from blood due to its glycan similarity. Histochemical staining with anti–Tf antibody and a lectin, specific probe for brain–type glycan, reveals that brain–type Tf is secreted from choroid plexus, CSF–producing tissue. Idiopathic normal pressure hydrocephalus (iNPH) is an elderly dementia caused by abnormal metabolism of CSF. Brain–type Tf levels decreased in in iNPH but rapidly returned to normal levels within 1–3 months after shunt surgery. This change was positively correlated with recovery from dementia at 11.8±7.7 months post–operation, suggesting that brain–type Tf is a prognostic marker for recovery from dementia after shunt surgery for iNPH.</p>

収録刊行物

  • 神経治療学

    神経治療学 37 (3), 331-334, 2020

    日本神経治療学会

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