Current challenges and future perspectives of iPSC-based neurotoxicity testing

Tsunemoto Kazunobu, Yamada Shigeru, Kanda Yasunari

doi:10.1254/fpj.20097

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ヒトiPS細胞を用いた中枢神経系の安全性評価
創薬シリーズ(8)創薬研究の新潮流(44)ヒトiPS細胞を用いた中枢神経系の安全性評価
ソウヤクシリーズ(8)ソウヤクケンキュウノシンチョウリュウ(44)ヒト iPS サイボウオモチイタチュウスウシンケイケイノアンゼンセイヒョウカ

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<p>Predicting drug-induced side effects in central nervous system is important because they can lead to the discontinuation of new drugs/candidates or the withdrawal of marketed drugs. Although many efforts are made, evaluation system using animals have not been highly predictive in humans. In addition, animal experiments are time-consuming and costly. To address these issues, in vitro evaluation methods, such as the use of New Approach Methodologies (NAM) have been explored. Human iPS cell technology has already been applied to assess drug-induced cardiotoxicity. In addition, the use of human iPS cell technology and in silico has been promoted for neurotoxicity assessment during the developmental neurotoxicity in terms of chemical safety issues. Organization for Economic Cooperation and Development (OECD) guidance regarding developmental neurotoxicity is under preparation. In this review, we will review the current trends in safety assessment methods for the central nervous system in light of these international trends.</p>

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Folia Pharmacologica Japonica

Folia Pharmacologica Japonica 156 (2), 107-113, 2021

The Japanese Pharmacological Society

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