T<sub>2</sub>-FLAIR Mismatch Sign Is Caused by Long T<sub>1</sub> and T<sub>2</sub> of <i>IDH</i>-mutant, 1p19q Non-codeleted Astrocytoma

  • Kinoshita Manabu
    Department of Neurosurgery, Osaka International Cancer Institute
  • Uchikoshi Masato
    Department of Neurosurgery, Osaka International Cancer Institute Canon Medical Systems Corporation
  • Sakai Mio
    Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute
  • Kanemura Yonehiro
    Department of Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital
  • Kishima Haruhiko
    Department of Neurosurgery, Osaka University Graduate School of Medicine
  • Nakanishi Katsuyuki
    Department of Diagnostic and Interventional Radiology, Osaka International Cancer Institute

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  • T2-FLAIR mismatch sign is caused by long T1 and T2 of IDH-mutant, 1p19q Non-codeleted Astrocytoma

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<p>T2-fluid-attenuated inversion recovery images (FLAIR) mismatch sign is now known to be a specific yet insensitive image feature for IDH-mutant, 1p19q non-codeleted astrocytoma. The current study revealed that lesion presenting T2-FLAIR mismatch exhibited extremely long T1- and T2-relaxation time while T2-FLAIR matched lesions showed low to moderate values. On the other hand, IDH-wildtype tumors presented noticeably short T1- and T2-relaxation time. These different relaxation time characteristics seemed to render T2-FLAIR mismatch sign of becoming such a unique and specific image feature for IDH-mutant, 1p19q non-codeleted astrocytoma.</p>

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