Impact of patient age on outcome after resection for hepatocellular carcinoma
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- Harada Masaharu
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Aramaki Osamu
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Midorikawa Yutaka
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Higaki Tokio
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Nakayama Hisashi
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Moriguchi Masamichi
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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- Takayama Tadatoshi
- Department of Digestive Surgery, Nihon University School of Medicine, Tokyo, Japan.
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Description
<p>There is little information on the impact of aging on liver resection of hepatocellular carcinoma (HCC). The aim of study was to evaluate the prognostic impact of the patient's age on the long-term survival after resection of HCC. The postoperative outcomes of the 291 elderly (≥ 70 years) and 340 younger (< 70 years) patients underwent curative liver resection for HCC were analyzed using multivariate and propensity-score matching. Risk score were calculated from the results of Cox regression analysis. The overall survival rate was significantly lower in the elderly group than that in the younger group (p = 0.01). Factors related to overall survival were vascular invasion (absent vs. present, HR 2.25; 95% CI 1.52-3.33, p = 0.0001), albumin level (< 3.0 vs. ≥ 3.0 g/dl, HR 2.23; 95% CI 1.31-3.79, p = 0.003), and number of tumors (solitary vs. multiple, HR 1.68; 95% CI 1.24-2.27, p = 0.001). The results of risk-score analysis with a Cox proportional-hazards model indicated that the proportion of poor-risk patients was significantly higher in the elderly than in the younger group. Propensity-score matching analysis yielded 234 pairs of patients. There were no significant differences in baseline profiles or risk scores between the two groups (p = 0.43). There were also no significant differences in the overall survival between the two groups (p = 0.23). Advanced age does not have a significant impact on the outcomes of patients after resection of HCC. </p>
Journal
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- BioScience Trends
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BioScience Trends 15 (1), 33-40, 2021-02-28
International Research and Cooperation Association for Bio & Socio-Sciences Advancement