速効性筋注製剤オランザピンの臨床的有効性の検証

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  • 井上 賀晶
    大分大学医学部附属病院 総合臨床研究センター

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  • Verification of Clinical Efficacy of Olanzapine Rapid Acting Injection

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<p>Background: Olanzapine 10mg intramuscular injection (IM) is new generation antipsychotic injection. As typical antipsychotic injection, many researches of Haloperidol 5mg IM efficacy for the treatment of acute agitation have been done. This study, I tried to verify the efficacy of Olanzapine 10mg IM against acute agitated patients (n=40) compared with Haloperidol 5mg IM (n=30) and Diazepam 10mg IM (n=20) with scaling Positive and Negative Syndrome Scale Excited Components (PANSS-EC) as assessment of agitation and Drug Induced Extrapyramidal Symptoms Scale (DIEPSS) as assessment of adverse event after injection. Conclusion: Through this clinical study, I could indicate that Olanzapine 10mg IM had same efficacy compared with Haloperidol 5mg and significant higher efficacy than Diazepam 10mg to decrease PANSS-EC scores. I also could indicate the interesting and significant differences in DIEPSS. I will make presentation at a conference. </p>

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