書誌事項
- タイトル別名
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- Nicotine attenuated chronic unpredictable mild stress-induced depressive-like behavior via elevation of serum corticosterone level
抄録
<p>Major depressive disorder (MDD) is a worldwide serious psychiatric disease, and more than 300 million people suffer from MDD. Chronic stress contributes to the pathogenesis of MDD. Cigarette smoking is strongly associated with MDD. Epidemiological and clinical studies claim that the smoking is assumed as self-medication for stress and depression. In this study, we investigated the effect of nicotine on the depression-like behavior induced by chronic unpredictable mild stress (CUMS). At the age of 6 weeks, C57BL6J mice were randomly exposed to 9 kinds of mild stressors for 4 weeks. Nicotine (0.2mg/kg), galantamine (1mg/kg) and varenicline (1mg/kg) were administrated 30 min before exposure to each stressor during CUMS. After CUMS, mice were subjected social interaction test and measured serum corticosterone levels and mRNA levels of nicotinic acetylcholine receptor (nAChR) subunits in the prefrontal cortex (PFC). Nicotine attenuated decrease in social interaction time of CUMS mice. Nicotine did not affect elevated serum corticosterone levels immediately after CUMS but reversed the sustained elevation after behavioral test. CUMS did not affect mRNA levels of α7, α4 or β2 nAChR subunit in the PFC. Finally, we evaluated the efficacies of galantamine, α7 nAChR allosteric modulator and varenicline, α4β2 nAChR partial agonist on CUMS mice. Administration of galantamine, but not varenicline attenuated decrease in social interaction time of CUMS mice. These data suggested that α7 nAChR is an important target for stress resilience and development of antidepressant.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 94 (0), 3-O-E2-1-, 2021
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390005966212265600
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- NII論文ID
- 130008001614
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可