細胞治療に向けたCFD-DEMによるマイクロ粒子の閉塞特性の解明

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  • Investigation of microparticles clogging in vessel using two-way CFD-DEM coupling method for cell therapy

抄録

<p>Recellularization is the process of the repopulation of organs with organ-specific cell types or stem cells through direct injection or continuous perfusion. However, vessel clogging is a serious problem reducing the efficiency of the seeding process. This process combines two complex phenomena, cell motion and fluid flow, into one challenging system where multiple parameters can influence the general outcome. Moreover, it is difficult to experimentally study the clogging phenomenon in the whole organ. Thus, in this study, we applied a resolved two-way CFD-DEM coupling approach to simulate the dynamic cell seeding under perfusion conditions. This work can provide some evaluations and predictions to enhance the efficiency of recellularization process.</p>

収録刊行物

  • 年次大会

    年次大会 2020 (0), J02301-, 2020

    一般社団法人 日本機械学会

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