書誌事項
- タイトル別名
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- Medicinal chemistry of vitamin A: Development of synthetic retinoid,Am80 (Tamibarotene) and future prospects
- ビタミンAの創薬化学 : 合成レチノイドAm80(タミバロテン)の開発と将来展望
- ビタミン A ノ ソウヤッカガク : ゴウセイ レチノイド Am80(タミバロテン)ノ カイハツ ト ショウライ テンボウ
- 特集 ―脂溶性ビタミン研究70 年―
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説明
Retinoid regulates various biological phenomena, such as cell proliferation, differentiation, morphogenesis, immunity, and metabolism, by binding and activating two types of nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Since the discovery of these nuclear receptors, various specific modulators for both RARs and RXRs have been developed. Among them, some RAR and RXR specific agonists including Am80 (tamibarotene), an RARα/ β-selective agonist are in clinical use. Based on the recent progress in the research on the retinoid functions, the potential clinical utilities of retinoids towards metabolic diseases, autoimmune diseases, and neurodegenerative diseases have been elucidated. Here, the development of synthetic retinoids in the last 30 years, and the future prospect of the retinoid therapy are overviewed.
収録刊行物
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- ビタミン
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ビタミン 94 (3), 137-142, 2020-03-25
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390006065654016384
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- NII論文ID
- 130008009221
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 030338495
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDLサーチ
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可