Comparison of EASI Improvement Rates by Dupilumab For Different Anatomical Regions in Atopic Dermatitis

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  • アトピー性皮膚炎におけるデュピルマブの部位別EASI改善率の検討
  • アトピーセイ ヒフエン ニ オケル デュピルマブ ノ ブイ ベツ EASI カイゼンリツ ノ ケントウ

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<p>Dupilumab was highly effective for refractory AD. There were no differences among the clinical effects for anatomical regions in the clinical trials. However, we did have cases that did not respond as well to dupilumab on the head and neck. In this study, we analyzed the EASI improvement rates at 4 weeks and 16 weeks after treatment in 34 patients who used dupilumab at our hospital for each of the following regions; head and neck, upper limbs, trunk and lower limbs. Our results showed that the EASI improvement rate at 16 weeks was significantly lower in the head and neck than in the other three regions. There were also cases in which only the head and neck were exacerbated. We discuss our results with consideration from the published reports.</p>

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