Evaluation of reactivity of HISCL<sup>TM</sup> SARS-CoV-2 antibody reagent

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  • KIKUCHI Ryosuke
    Department of Medical Technique, Nagoya University Hospital
  • SUZUKI Atsuo
    Department of Medical Technique, Nagoya University Hospital
  • KIM Jeong Hui
    Department of Medical Technique, Nagoya University Hospital
  • WATARAI Rika
    Department of Medical Technique, Nagoya University Hospital
  • MORISE Masahiro
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
  • SAITO Shoji
    Department of Nephrology, Nagoya University Graduate School of Medicine
  • YAGI Tetsuya
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine
  • MATSUSHITA Tadashi
    Department of Clinical Laboratory and Transfusion Medicine, Nagoya University Hospital

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Other Title
  • HISCL<sup>TM</sup> SARS-CoV-2抗体試薬の反応性評価
  • HISCL SARS-CoV-2抗体試薬の反応性評価
  • HISCL SARS-CoV-2 コウタイ シヤク ノ ハンノウセイ ヒョウカ

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Abstract

<p>Antibody detection reagents for the novel coronavirus SARS-CoV-2 can be classified into two types: those that detect antibodies to the spike protein S1 domain (S) and/or the nucleocapsid protein (N) of SARS-CoV-2. In this study, we evaluated the reactivity of the HISCLTM SARS-CoV-2 antibody reagent in three cases of COVID-19. In case 1, IgM antibodies were detected when using the HISCLTM SARS-CoV-2 S-IgM reagent from the time of admission to the hospital (day X). In case 2, SARS-CoV-2 antibodies were detected when using the HISCL SARS-CoV-2 S-IgM, N-IgM, and N-IgG reagents from the X + 1st day, and IgG antibodies were detected from the X + 2nd day when using the HISCLTM SARS-CoV-2 S-IgG reagent . In case 3, positive results were obtained from X + 12th day for the HISCLTM SARS-CoV-2 S-IgM and S-IgG reagents. These results suggest that among the HISCLTM SARS-CoV-2 reagents, the S-targeting antibody reagent could detect SARS-CoV-2 antibodies earlier than the N-targeting antibody reagent.</p>

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