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Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study

  • Kihara Tomomi
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
  • Yamagishi Kazumasa
    Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
  • Honda Kazufumi
    Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute
  • Ikeda Ai
    Department of Public Health, Juntendo University Graduate School of Medicine
  • Yatsuya Hiroshi
    Department of Public Health, Fujita Health University School of Medicine
  • Saito Isao
    Department of Public Health and Epidemiology, Faculty of Medicine, Oita University
  • Kokubo Yoshihiro
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center
  • Yamaji Taiki
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • Shimazu Taichi
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • Sawada Norie
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • Iwasaki Motoki
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center
  • Iso Hiroyasu
    Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba
  • Tsugane Shoichiro
    Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center

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Abstract

<p>Aim: The fact that low concentrations of high-density lipoprotein cholesterol are associated with the risk of cardiovascular disease is well known, but high-density lipoprotein metabolism has not been fully understood. Apolipoprotein A2 (ApoA2) is the second-most dominant apolipoprotein of high-density lipoprotein. We tested the hypothesis that ApoA2 isoforms are inversely associated with myocardial infarction. </p><p>Methods: We measured the plasma levels of three ApoA2 isoforms (ApoA2-ATQ/ATQ, ApoA2-ATQ/AT, ApoA2-AT/AT) in nested case-control study samples of 1:2 from the Japan Public Health-Center-based Study (JPHC Study): 106 myocardial infarction incidence cases and 212 controls. </p><p>Results: ApoA2-AT/AT was inversely associated with risk of myocardial infarction, in a matched model (OR, 2.78; 95% CI, 1.26–6.09 for lowest compared with the highest quartile), but its association was attenuated after adjustment for smoking only (OR=2.13; 95% CI, 0.91–4.97) or drinking only (OR=2.11; 0.91–4.89), and the multivariable OR was 1.20 (95% CI, 0.41–3.57). Neither ApoA2-ATQ/ATQ nor ApoA2-ATQ/AT was associated with the risk of myocardial infarction. </p><p>Conclusions: Our nested case-control study did not show a significant association of ApoA2 isoforms with a risk of myocardial infarction. </p>

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