A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications

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  • Sulastri Evi
    Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Tadulako
  • Lesmana Ronny
    Department of Anatomy, Physiology and Biology Cell, Faculty of Medicine, Universitas Padjadjaran
  • Zubair Muhammad Sulaiman
    Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Tadulako
  • Elamin Khaled M.
    Global Center for Natural Resources Sciences, Faculty of Life Sciences, Kumamoto University
  • Wathoni Nasrul
    Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran

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<p>Ulvan is a natural sulfated polysaccharide obtained from marine green algae composed of 3-sulfated rhamnoglucuronan as the main component. It has a unique chemical structure that rich of L-rhamnosa, D-glucuronic acid, and L-iduronic acid. Ulvan has a similar structure to glycosaminoglycans (GAGs) in mammals including chondroitin sulfate, dermatan sulfate, and heparan sulfate that has broad range applications for many years. Here, we provide an overview of ulvan based hydrogels for biomedical applications. Hydrogels are one of ulvan advances in polymer science for application in drug delivery, tissue engineering, and wound healing. This review presented an overview about functional information of ulvan based hydrogels and the promising potential in biomedicals collected from published papers in Scopus, PubMed, and Google Scholar. Other important aspects concerning properties, hydrogel-forming mechanisms, and ulvan based hydrogel developments were reported as well. As conclusion, ulvan showed interesting properties in forming hydrogels and promising advances in biomedical applications.</p>

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