Measurement of Regional Tissue Hemoglobin Oxygen Saturation in Humans Using Optical Spectroscopy

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  • Sakai Akio
    Department of Environmental Physiology, Institute of Cardiovascular Disease, Shinshu University School of Medicine
  • Saito Tateo
    Biomedical Science Co.
  • Azuma Kouzo
    Biomedical Science Co.
  • Yanagidaira Yasunori
    Department of Environmental Physiology, Institute of Cardiovascular Disease, Shinshu University School of Medicine
  • Asano Koji
    Department of Environmental Physiology, Institute of Cardiovascular Disease, Shinshu University School of Medicine

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  • 組織酸素飽和度(StO_2)およびヘモグロビン量(Hb vol)測定装置の開発

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If the light is inserted into the surface of the tissue, the distribution of the intensity of the light will form the shape of a hemisphere because of the strong scattering of light. So the intensity of the light obtained at a certain depth from the point of insertion is considered equal to that of the light obtained from the same distance on the surface. If we apply Lambert-Beer's law to the increase of absorption in blood flow when pressure is canceled, we can determine the oxygen saturation level of the blood (StO_2) and hemoglobin volume (Hb vol) in the tissue non-invasively and continuously. We made a device based on this theory and then conducted experiments on cold-induced vasooscillation and on low pressure. We found that there is a high correlation between Hb volume and skin temperature under cold : StO_2 and StO_2 under low pressure : StO_2 and SvO_2 under low pressure. Fore the reasons mentioned above, we can conclude that our device is very useful for premedical and clinical medicine.

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