A case of secondary membranous nephropathy in a patient with psoriasis vulgaris

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  • Taniguchi Yukihiro
    Department of Internal Medicine, Sainokuni Higashiomiya Medical Center, Saitama, Japan
  • Saito Eiichiro
    Department of Internal Medicine, Sendai City Hospital, Sendai, Japan
  • Oikawa Hiroki
    Department of Pathology, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Tanaka Fumitaka
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Watanabe Shuji
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Oikawa Kanta
    Department of Pathology, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Akasaka Yuichiro
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Matsuura Yuki
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Noda Seiya
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Asahi Koichi
    Division of Nephrology and Hypertension, Department of Internal Medicine, School of Medicine, Iwate Medical University, Yahaba, Japan

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Other Title
  • 尋常性乾癬患者に発症した二次性膜性腎症の1例
  • ジンジョウセイカンセンカンジャ ニ ハッショウ シタ ニジセイマクセイジンショウ ノ 1レイ

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A man in his 60s was diagnosed with psoriasis vulgaris 10 years ago and was on phototherapy and topical therapy with glucocorticosteroids. Although he noticed edema of the lower extremities 2 years ago, his condition improved following medication with loop diuretics. However, the edema recurred 2 months ago and he was referred to our hospital with suspected nephrotic syndrome. Laboratory data showed evidence of nephrotic syndrome. Collagen disease was ruled out because antinuclear antibody and rheumatoid factor were not detected, and complements showed normal ranges. There was no infection with hepatitis B virus or C virus. Renal biopsy revealed findings of secondary membranous nephropathy. Autoimmune disease, viral hepatitis, and malignancies are secondary etiologies of membranous glomerulopathy. Examinations using gastrointestinal endoscopy and computed tomography of the region from the thorax to the pelvis showed no neoplastic lesions. In rare cases of membranous nephropathy, an association with psoriasis vulgaris has been suggested. Therefore, the renal disorder in this case was presumed to be secondary to psoriasis vulgaris.

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