-
- Murakami Manabu
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
-
- Nemoto Takayuki
- Department of Pharmacology, Graduate School of Medicine, University of Miyazaki
-
- Niwa Hidetoshi
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
-
- Kushikata Tetsuya
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
-
- Ono Kyouichi
- Department of Cellphysiology, Akita University School of Medicine
-
- Watanabe Hiroyuki
- Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine
-
- Hirota Kazuyoshi
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
-
- Ohba Takayoshi
- Department of Cellphysiology, Akita University School of Medicine
この論文をさがす
抄録
Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.<br> Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.<br> Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.<br> Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal medulla.
収録刊行物
-
- 弘前医学
-
弘前医学 65 (2-4), 218-226, 2014
弘前大学大学院医学研究科・弘前医学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390006895527186176
-
- NII論文ID
- 110009838284
-
- NII書誌ID
- AN00211444
-
- ISSN
- 24344656
- 04391721
-
- HANDLE
- 10129/5430
-
- NDL書誌ID
- 025848701
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可