Involvement of endothelin-1 in adrenal catecholamine regulation

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  • Murakami Manabu
    Department of Pharmacology, Hirosaki University Graduate School of Medicine
  • Nemoto Takayuki
    Department of Pharmacology, Graduate School of Medicine, University of Miyazaki
  • Niwa Hidetoshi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Kushikata Tetsuya
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Ono Kyouichi
    Department of Cellphysiology, Akita University School of Medicine
  • Watanabe Hiroyuki
    Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine
  • Hirota Kazuyoshi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine
  • Ohba Takayoshi
    Department of Cellphysiology, Akita University School of Medicine

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Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.<br> Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.<br> Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.<br> Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal medulla.

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  • 弘前医学

    弘前医学 65 (2-4), 218-226, 2014

    弘前大学大学院医学研究科・弘前医学会

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