Effects of dietary ethanol extract from fruiting bodies of golden oyster mushroom (<i>Pleurotus citrinopileatus</i>) on chronic colon inflammation in mice treated with dextran sulfate sodium salt

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  • YAMASHITA Shinji
    1) Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
  • AKADA Kota
    1) Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
  • MATSUMOTO Satoshi
    2) L/S Corporation, 5F, Kyodo Bldg. 13-4 Nihonbashi Kodenma, Chuo-ku, Tokyo 103-0001, Japan
  • KINOSHITA Mikio
    1) Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan

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Other Title
  • DSS誘導潰瘍性大腸炎モデルマウスにおけるタモギタケ（Pleurotus citrinopileatus）子実体エタノール抽出物摂取の効果
  • Effects of dietary ethanol extract from fruiting bodies of golden oyster mushroom (Pleurotus citrinopileatus) on chronic colon inflammation in mice treated with dextran sulfate sodium salt

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In recent years, the incidence of intestinal impairments, such as colon cancer and inflammatory bowel disease (IBD), has been increasing in East Asian countries. Healthy dietary habits, as well as taking dietary supplements, are seen as important to preventing these impairments. Mushrooms and the hydrophilic fraction are commonly recognized for multiple nutritious functions, while the function of the lipophilic fraction remains uncertain. In this study, we investigated the effects of the lipophilic fraction containing sphingolipids, extracted from Pleurotus citrinopileatus (golden oyster mushroom), on mice suffering from chronic colon inflammation by treatment of dextran sulfate sodium salt (DSS) as IBD models. In the experiment, mice were fed with (1) control AIN-76 standard diet or (2) AIN-76 diet supplemented with 1% ethanol extract from fruiting bodies of golden oyster mushroom (GOMEE) or (3) AIN-76 diet supplemented with 5% GOMEE. Subsequent to experimental diets for 10 days, mice were drinking water ad libitum supplemented with DSS. We found that in mice ingesting DSS for 26 days, dietary GOMEE suppressed the body weight reduction and the spleen weight increase by administration of DSS. Dietary GOMEE decreased DSS-induced chorionic crypt injury, and the ameliorative effect by 5% GOMEE diet was stronger when compared to the 1% GOMEE diet. Moreover, we researched the impact of GOMEE on the early/middle stage of inflammation in colon mucosa, by assessing levels of inflammation-related cytokines in mice ingesting DSS for 18 days. The levels of almost inflammatory cytokines and chemokines examined in the colon were significantly increased due to DSS ingestion. Dietary 5% GOMEE was correlated with a significant decrease in the levels of 5 inflammatory cytokines and 5 chemokines. These results suggested that dietary GOMEE contributes to suppression of colon inflammation and the effect is dose-dependent.

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